据parvalbumin内部神经元报告的,大皮层中的柱子和层之间传导的速度
Katherine S Scheuer1, John M Judge2, Xinyu Zhao3,4
1Cellular and Molecular Biology Program, University of Wisconsin-Madison, Madison, WI 53705, United States.
Cerebral cortex (New York, N.Y. : 1991)
|July 6, 2023
概括
帕瓦胺 (PV) 内神经元迅速控制大脑电路. 新的成像显示,内膜间信号比内膜内信号快71% ,这影响了前皮层的感官处理.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 细胞神经科学 细胞神经科学
背景情况:
- 帕瓦胺 (PV) 内神经元对于大脑电路动力学至关重要,在毫秒时间尺度上运行.
- 通过刺激途径激活PV内部神经元的精确时间决定了它们的功能作用.
研究的目的:
- 通过使用先进的电压成像来研究体感管皮质 (BC) 中的PV内部神经元的导电速度.
- 为了比较BC内的内膜间和内膜内传导速度.
主要方法:
- 利用一种基因编码的混合电压传感器,在成年小鼠BC中对PV内部神经元进行次毫秒电压成像.
- 采用电刺激来唤起和测量脱极化延迟,根据距离确定传导速度.
主要成果:
- 导电速度从74到473微米/秒不等,取决于轴突轨迹.
- 间层导电 (71%更快) 在皮层内明显超过了内层导电.
- 证明在皮层列中的计算比列之间的计算更快.
结论:
- 内部和间层PV内部神经元激活时间的差异可以显著影响BC功能,如感官处理.
- 对光伏内神经元的电压成像提供了对皮质电路信号动态和轴突准特异性的洞察.
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