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Updated: Jul 24, 2025

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
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分子动力学和机器学习研究GPCR的绑定口袋中的上腺素动力学

Keshavan Seshadri1, Marimuthu Krishnan1

  • 1Center for Computational Natural Sciences and Bioinformatics (CCNSB), International Institute of Information Technology, Gachibowli, Hyderabad 500032, India.

Journal of chemical information and modeling
|July 7, 2023
PubMed
概括

这项研究使用分子动力学模拟揭示了与上腺素结合的β-2上腺体受体 (β2AR) 的两个关键状态. 了解这些受体-连接体动态对于设计新的G蛋白结合受体 (GPCR) 药物至关重要.

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