优泉囊中的化学成分的定性和定量分析,采用超高性能液态染色学和质谱学
Fangfang Wu1, Zhien Tan1, Taiping Li1,2
1National Engineering Laboratory for the Development of Southwestern Endangered, Medicinal Materials, Guangxi Botanical Garden of Medicinal Plants, Nanning, P. R. China.
Journal of separation science
|July 7, 2023
概括
这项研究用先进的染色学和质谱学对优泉囊中的116种化合物进行了表征,优泉囊是一种治疗糖尿病的传统中医药. 这为质量控制和进一步研究提供了全面的化学特征.
科学领域:
- 药理学和中国传统医学
- 分析化学 分析化学
- 自然产品化学 自然产品化学
背景情况:
- 玉泉囊是一种广泛使用的中国传统专利医学,用于治疗糖尿病.
- 了解Yuquan囊的化学成分对于质量控制和有效性至关重要.
- 现有的分析方法可能无法提供全面的化学特征.
研究的目的:
- 建立一个高吞吐量分析方法,用于全面的化学概况Yuquan囊.
- 为了识别和表征在Yuquan囊中存在的化学成分.
- 为优泉囊的质量评估和药学动力学研究提供参考.
主要方法:
- 超高性能液态染色学-飞行质谱四极时间 (UPLC-QTOF-MS) 用于高通量识别.
- 碎片分析和自然产品的UNIFI处理用于数据解释.
- 超高性能液体染色学-并联三四极质谱学 (UPLC-MS/MS) 用于对生物活性化合物的定量分析.
主要成果:
- 成功建立了一种新的Yuquan囊高通量分析方法.
- 在Yuquan囊中描述了总共116种化合物.
- 定量分析了12种关键生物活性化合物,确定了它们的含量.
结论:
- 这项研究使用先进的分析技术提供了Yuquan囊的第一个全面的化学概况.
- 建立的方法和特征化合物作为质量控制和标准化Yuquan制剂的重要参考.
- 详细的化学数据有助于未来对优泉囊在糖尿病治疗效果的药理学研究.
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