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Updated: Jul 24, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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激活转录因子的选择性蛋白解通过NIR响应的Palindromic DNA Thalidomide结合物抑制了正规的Smad路径

Min Hou1,2, Rui Guo1, Tianyu Ren1

  • 1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biomedical Sciences, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.

Small (Weinheim an der Bergstrasse, Germany)
|July 7, 2023
PubMed
概括

一种新型的Palindromic DNA结合物 (PASTE) 选择性地降解激活的转录因子,为难以获得药物的目标提供了一种新方法. 这种PROTAC技术对精准医学和研究疾病途径具有前途.

关键词:
在TGF-β/Smad中.一个aptamer的应用程序.光学控制器的光学控制器是什么蛋白质降解 蛋白质降解转录因子的转录因子上转化纳米粒子 (UCNPs) 的使用

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