由RNA病毒编码的小型非编码RNA:古老的争议和来自COVID-19大流行的新教训
Carolina Ruivinho1, Margarida Gama-Carvalho1
1BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisboa, Portugal.
Frontiers in genetics
|July 7, 2023
概括
新兴的RNA病毒编码小的非编码RNA (sncRNAs),如病毒微RNA (v-miRNAs),可以调节感染. 研究强调它们在宿主免疫力,复制和作为生物标志物和治疗点的潜力中的作用.
科学领域:
- 病毒学 病毒学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- RNA病毒爆发需要了解病毒机制和病变发生.
- 蛋白质层面的相互作用得到了充分的研究,但RNA介导的相互作用却得到了较少的探索.
- 小型非编码RNAs (sncRNAs),包括病毒miRNAs (v-miRNAs),被RNA病毒编码,并影响宿主-病原体动态.
研究的目的:
- 提供病毒sncRNA的最新概述,重点关注RNA病毒编码的v-miRNA.
- 为了探索v-miRNAs的作用机制.
- 讨论它们作为诊断/预后生物标志物和治疗点的潜力.
主要方法:
- 对病毒 ncRNA 资料库的公共数据库的分析.
- 审查出版趋势,特别是COVID-19流行后的趋势.
- 综合当前关于v-miRNA生物发生,流行和功能的知识.
主要成果:
- 病毒的sncRNAs,特别是v-miRNAs,在调节宿主免疫反应和病毒复制中起着至关重要的作用.
- 这些分子准病毒或宿主转录以发挥其功能.
- 近年来,人们在理解它们的生物发生,流行和功能相关性方面看到了范式的转变.
结论:
- 持续的研究对于完全描述由RNA病毒编码的sncRNAs至关重要.
- 识别研究这些分子的陷对于准确的评估至关重要.
- 病毒sncRNAs代表了诊断,预后和抗病毒疗法的有希望的途径.
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