在口腔中,LAMC2通过Pl3K/AKT/mTOR通路调节的增殖,迁移和入侵
Fayu Shan1, Lanlan Liang1, Chong Feng1
1Department of Environmental Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, 300070, China.
Oncology research
|July 7, 2023
概括
低调拉米宁玛2 (LAMC2) 激活自并通过向PI3K/AKT/mTOR通路来抑制口腔状细胞癌 (OSCC) 的进展. 协同的LAMC2和自调节为OSCC提供了一个新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的恶性瘤.
- 拉米宁玛2 (LAMC2) 和自在OSCC病变发生中的作用需要进一步阐明.
- 了解LAMC2信号和自相互作用对OSCC研究至关重要.
研究的目的:
- 在OSCC开发中研究LAMC2信号的机制.
- 探索自在OSCC中的参与和功能.
- 在OSCC中分析LAMC2,自和PI3K/AKT/mTOR通路之间的相互作用.
主要方法:
- 使用小干扰RNA (siRNA) 下调LAMC2.
- 细胞测试 (增殖,入侵,迁移) 和*in vivo*异种移植模型评估了OSCC的行为.
- 使用RFP-LC3监测自水平,并分析PI3K/AKT/mTOR通路.
主要成果:
- 低调LAMC2激活了自,抑制了OSCC的扩散,入侵和转移.
- 对PI3K/AKT/mTOR通路的抑制在LAMC2敲击和随后的自激活时被观察到.
- 自在OSCC中表现出双重作用,具有协同下调LAMC2和自抑制瘤进展的协同作用.
结论:
- 通过PI3K/AKT/mTOR通路,LAMC2和自共同调节OSCC转移,入侵和扩散.
- 同时降低LAMC2的调节和自的调节是一个有希望的策略来抑制OSCC.
- 针对LAMC2-自轴为口腔状细胞癌提供了潜在的治疗途径.
更多相关视频
07:39Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
180
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
18.0K
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
3.7K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.7K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
