对老年人抑郁症的维生素D补充:随机对照试验的元分析
Yoonjung Park1,2, Young-Mi Ah3, Yun Mi Yu1,2
1Department of Industrial Pharmaceutical Science, Yonsei University, Incheon, Republic of Korea.
Frontiers in nutrition
|July 7, 2023
概括
维生素D补充剂在60岁及以上的成年人中没有改善抑郁症状. 这一对随机对照试验的分析发现,接受维生素D的老年人对抑郁症没有显著的益处. 需要进一步研究.
科学领域:
- 老年学是一门学科.
- 营养精神病学 营养精神病学
- 临床流行病学临床流行病学
背景情况:
- 老年人的抑郁症与认知障碍和生活质量下降有关.
- 之前关于维生素D和老年人的抑郁症的研究已经产生了相互矛盾的结果.
- 本次元分析探讨了维生素D与老年人抑郁症之间的有争议的关系.
研究的目的:
- 研究维生素D补充剂对60岁及以上人群抑郁症状的影响.
- 分析随机对照试验 (RCT) 的数据,以确定疗效.
- 为了评估对既有抑郁症诊断的,也没有抑郁症诊断的个人的影响.
主要方法:
- 在 MEDLINE,CENTRAL,Embase 和 PsycINFO 数据库进行系统搜索,截至 2022 年 11 月.
- 包括对年龄≥60岁参与者维生素D补充剂与安慰剂进行比较的RCT.
- 由于研究异质性,使用随机效应模型进行元分析,通过偏差风险评估质量 2.
主要成果:
- 分析了7项试验,涉及752名参与者 (主要结果) 和4385名参与者 (次要结果).
- 在前后得分变化 (SMD = -0.49,p = 0.10) 中没有观察到抑郁症状的统计学显著改善.
- 干预后的得分没有显著改善 (SMD = -0.10,p = 0.25).
结论:
- 补充维生素D似乎没有改善老年人的抑郁症状.
- 目前的证据不支持在这个年龄段使用维生素D来治疗抑郁症.
- 需要进一步的研究来进一步阐明维生素D在老年抑郁症中的作用.
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