补充COVID-19后的大脑:基因中链甘油三补充剂的潜在作用:一个假设
Angela G Juby1, Stephen C Cunnane2, Diana R Mager3
1Division of Geriatrics, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Frontiers in nutrition
|July 7, 2023
概括
后COVID-19认知功能障碍或"脑雾"影响了许多人,尤其是年轻女性. 中链甘油三酸 (MCTs) 可能改善长期COVID患者的大脑能量代谢和认知功能.
科学领域:
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 感染可能导致持续的认知功能障碍,称为"脑雾",影响日常功能,特别是在年轻女性中.
- 这种认知障碍与大脑葡萄糖代谢的改变有关,18F-氧葡萄糖-正子发射断层扫描 (FDG-PET) 扫描显示的异常模式证明了这一点.
- 在像阿尔茨海默氏症这样的疾病中观察到类似的代谢变化,这表明潜在的重叠病理.
研究的目的:
- 调查中链甘油三酸 (MCTs) 在COVID-19后认知功能障碍中减轻大脑葡萄糖低代谢的潜力.
- 假设MCT补充可以改善长期COVID症状的个体的认知功能.
- 鼓励进行临床试验,评估MCT在治疗COVID-19后认知障碍方面的有效性.
主要方法:
- 在COVID-19后的患者中,使用18F-氧葡萄糖-正子发射断层扫描 (FDG-PET) 评估大脑葡萄糖代谢.
- 将FDG-PET发现与年龄和性别匹配的对照和阿尔茨海默病中观察到的模式进行比较.
- 探索MCTs作为体的外源来源,以增强大脑能量代谢.
主要成果:
- 在COVID-19后的患者中,FDG-PET扫描显示大脑葡萄糖代谢受损,其模式类似于阿尔茨海默病.
- 由MCT补充剂促进的体,在葡萄糖低代谢的情况下,有望改善大脑能量代谢.
- MCT为营养症提供了一条可行且安全的途径,可能缓解认知缺陷.
结论:
- 假设MCT补充剂是改善认知功能的可行策略,并减少长期COVID中脑雾的持续时间/严重程度.
- 多重复合并疗法耐受性很好,具有成本效益,并具有强大的安全性,这使得它们成为一个有吸引力的干预措施.
- 需要进一步进行临床试验,以验证MCT在COVID-19后的认知后果方面的治疗潜力.
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