相关实验视频

Updated: Jul 24, 2025

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.3K

在β细胞移植中结合的小岛保护性治疗方法:使用目标产品配置文件设计合理的解决方案

Katie Lu1,2, Timothy Brauns1, Ann E Sluder1

  • 1Vaccine and Immunotherapy Center Massachusetts General Hospital Boston Massachusetts USA.

FASEB bioAdvances
|July 7, 2023
PubMed
概括

岛屿细胞移植 (ICT) 对1型糖尿病具有前景,但需要定义的目标产品配置文件 (TPP) 和组合方法来克服障碍. 这一策略可以改善长期的小岛功能和免疫保护,以便更广泛地采用.

关键词:
基板到床边开发的发展.结合的方法是组合的方法.岛屿细胞移植 岛屿细胞移植目标产品简介的目标产品简介.第1类糖尿病 1型糖尿病

更多相关视频

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.9K
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.2K

相关概念视频

Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
437
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
365