COVID-19的遗传关联与泌尿生殖系统症状
Zhenglin Chang1,2,3, Lingyue An4, Min Lei5,6
1Department of Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Frontiers in immunology
|July 7, 2023
概括
COVID-19增加了下泌尿道结石和性功能障碍的风险. 然而,它可能会对尿路感染和膀癌产生保护作用,而炎症可能会调解这些影响.
科学领域:
- 遗传学和流行病学
- 传染性疾病 传染性疾病
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
背景情况:
- 新出现的报道表明,COVID-19患者在出院后会出现生殖尿路症状.
- 这些症状的因果关系和机制在很大程度上是未知的.
- 了解这些关联对于患者管理至关重要.
研究的目的:
- 为了调查COVID-19和生殖尿路症状之间的因果关系.
- 探索这些关联的潜在分子机制.
- 为COVID-19后的护理提供基于证据的建议.
主要方法:
- 利用基因组广泛协会研究 (GWAS) 对COVID-19和28种生殖尿路症状的统计数据.
- 应用门德尔随机化 (MR) 分析使用单核酸多态化作为仪器变量.
- 进行了元分析,权重基因同表达网络分析 (WGCNA) 和丰富分析.
主要成果:
- COVID-19因果关系与下泌尿道结石 (LUTC) 和性功能障碍 (SD) 的风险增加有关.
- COVID-19 显示对尿路感染 (UTI) 和膀癌 (BLCA) 有潜在的保护作用.
- 确定了炎症免疫反应途径作为潜在的调解者.
结论:
- 建议加强对COVID-19患者的LUTC预防和SD监测.
- 强调需要承认对尿路感染和BLCA的潜在积极影响.
- 表明炎症免疫反应可能会将COVID-19与生殖尿路疾病联系起来.
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