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在印度中部疑似结核病例中的非结核菌分子鉴定
Malti Dadheech1, Anvita Gupta Malhotra1, Sakshi Patel1
1Department of Microbiology, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Cureus
|July 7, 2023
概括
准确识别Mycobacterium结核复合体 (MTBC) 和非结核菌 (NTM) 对于结核诊断至关重要. 在疑似结核病例中,分子方法有效地将MTBC与NTM区分开来,防止误诊并确保适当的患者管理.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断
背景情况:
- 准确识别Mycobacterium结核复合体 (MTBC) 对于结核病 (TB) 的诊断和管理至关重要.
- 非结核菌 (NTM) 可能被误认为是MTBC,导致错误的诊断和无效的治疗.
研究的目的:
- 用分子方法在印度中部怀疑结核病的患者中识别NTM.
- 在临床样本中区分MTBC和NTM.
主要方法:
- 400名疑似结核病患者的前性研究.
- 使用了液体培养 (MGIT),SD Bioline Ag MPT64测试,多重PCR (mPCR) 和GenoType® Mycobacterium常见菌根 (CM) 试验.
- 分子技术用于分化和识别菌根菌种.
主要成果:
- 在400个样本中,59个 (14.7%) 呈真菌菌的阳性.
- 在59种阳性培养中,12种 (20.33%) 被确定为NTM,47种 (79.67%) 被确定为MTBC.
- 在NTM分离物中,包括Mycobacterium fortuitum,Mycobacterium abscessus和Mycobacterium tuberculosis.这些分离物中,有大量的细菌.
结论:
- 分子方法对于在疑似结核病例中精确识别真菌菌种是有价值的.
- NTM的患病率凸显了区分MTBC和NTM的重要性,以避免误诊.
- 这项研究有助于了解印度中部NTM的流行病学和临床意义.
关键词:
线式探针测试试验 线式探针测试试验分子诊断 分子诊断 分子诊断这种的原因是mycobacterium.这种细菌是mycobacterium fortuitumitum.结核病菌菌菌的结核病菌的结核病.没有结核的真菌菌.更多相关视频
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