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甲甲酸诱导的类似中风综合征:一种罕见并发症的典型表现
Mariana Leitão Santos1, Sílvia Silva2, Amélia Moreira3
1Pediatric Medicine, Hospital de Braga, Braga, PRT.
Cureus
|July 7, 2023
概括
在急性淋巴细胞白血病 (ALL) 患者中,美托雷克萨特 (MTX) 可以引起类似中风的神经毒性. 这一案例突出了MTX治疗后的一种罕见但可逆的神经并发症,强调了迅速识别和特征性成像发现.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 甲托雷克萨特 (MTX) 是治疗急性淋巴细胞白血病 (ALL) 的关键药物.
- MTX可以诱导神经毒性,特别是影响中枢神经系统 (CNS) 的白质.
- 类似中风的综合征是一个公认的MTX神经毒性表现.
研究的目的:
- 报告一种MTX诱导的神经毒性病例,呈现为类似中风的综合征.
- 为了说明这种罕见并发症的临床和放射性特征.
- 为了强调神经系统完全恢复的潜力.
主要方法:
- 一个12岁男孩患有B-ALL的案例报告.
- 神经系统症状的临床表现 静脉内后的MTX.
- 大脑MRI与血管MRI一起评估神经毒性.
主要成果:
- 患者在内MTX后11天出现了突然的神经缺陷 (,失语,困惑).
- 大脑MRI揭示了半膜中心的双边受限扩散.
- 神经症状在短时间内自发消失.
结论:
- 在小儿ALL患者中,MTX诱导的神经毒性可以模仿中风.
- 典型的MRI发现支持了诊断.
- 及时识别和理解MTX副作用对于管理ALL患者至关重要.
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