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血管认知障碍患者的神经血管合改变:ASL-fMRI综合分析

Zhao Ruan¹, Dong Sun², Xiaoli Zhou¹

¹Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.

Frontiers in aging neuroscience

|July 7, 2023

概括

神经血管合 (NVC) 在血管认知障碍 (VCI) 中减少,调解白质病变和认知衰退之间的联系. NVC显示了评估VCI和受影响的神经回路的潜力.

科学领域:

神经科学是一个神经科学.
血管生物学血管生物学
认知科学认知科学

背景情况:

血管认知障碍 (VCI) 包括与脑血管疾病相关的认知缺陷.
白质病变 (WMLs) 在VCI中很常见,并影响认知功能.
神经血管合 (NVC),神经元活动和血液流动之间的关系,与VCI有关.

研究的目的:

调查NVC在VCI中的作用.
检查WML负担,NVC和VCI患者的认知缺陷之间的关系.
探索NVC作为VCI及其潜在的神经机制的生物标志物.

主要方法:

研究包括38名小血管疾病认知障碍 (SVCI) 患者,34名中风后认知障碍 (PSCI) 患者和43名健康对照 (HC).
神经成像和神经心理测试被用来评估认知功能和WML负担.
调解分析探讨了NVC,WML负担和认知障碍之间的关系.

主要成果:

与HC相比,NVC在SVCI和PSCI组显著减少.
在参与认知控制和情绪调节的大脑区域观察到减少的NVC.
调解分析证实了NVC在WML负担和认知障碍之间的调解作用.

结论:

在与VCI相关的认知障碍中,NVC起着重要的调解作用.
在VCI中,NVC是评估认知障碍的潜在措施.
在VCI中,NVC可以帮助识别受WML负担影响的特定神经回路.

关键词:

大脑小血管疾病是大脑小血管疾病.神经血管合器的神经血管合器在中风后的认知障碍.血管性认知障碍血管性认知障碍白质病变白质病变

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