一种改善famotidine特性的一种方法
Yongfeng Zhao1, Ying Fan2, Yan Zhang3
1College of Pharmacy, Qingdao University, Qingdao, 266071, China.
Heliyon
|July 7, 2023
概括
研究人员使用m-nitrobenzoic acid (MNBA) 开发了一种新的famotidine (FMT) 盐共晶,以提高药物的透性. 这种晶体工程方法改善了像FMT这样的低透性药物的输送.
科学领域:
- 制药科学 制药科学
- 晶体工程公司 晶体工程
- 药物运输 药物运输 药物运输
背景情况:
- 芳丁 (FMT) 是一种BCSIII类药物,具有低透性,限制了其治疗疗效.
- 晶体工程提供了修改药物特性 (包括透性) 的策略.
- 开发新型共晶对于改善透性差的药物的生物可用性至关重要.
研究的目的:
- 使用m-nitrobenzoic acid (MNBA) 作为辅制剂合成稳定的 famotidine (FMT) 盐共晶.
- 描述新型FMT-MNBA共晶体的物理化学特性.
- 评估共结晶对 famotidine 溶解性和透性的影响.
主要方法:
- 用m-nitrobenzoic 酸对 famotidine 的联合结晶.
- 使用扫描电子显微镜,DSC,TGA,FTIR和XRD (粉末和单晶) 进行表征.
- 对合成的共晶的可溶性和透性的评估.
主要成果:
- 一个稳定的1:1盐共晶的 famotidine-m-nitrobenzoic 酸 (FMT-MNBA) 成功合成和结构性特征.
- 与自由 famotidine 相比,FMT-MNBA 共同晶体表现出更好的透性.
- 该研究表明了晶体工程在提高药物透性的潜力.
结论:
- 合成的FMT-MNBA盐共晶代表了改善BCSIII类药物的透性的可行策略.
- 这种晶体工程方法为开发低透性的药物提供了有价值的方法.
- 对共晶形成的进一步研究可以推动开发更有效的药物配方.
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