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一种近红外光可激活的Ru(ii) - 库马林光敏剂,在低氧条件下活跃

Enrique Ortega-Forte¹, Anna Rovira², Marta López-Corrales²

¹Departamento de Química Inorgánica, Universidad de Murcia, Biomedical Research Institute of Murcia (IMIB-Arrixaca) E-30071 Murcia Spain jruiz@um.es.

Chemical science

|July 7, 2023

概括

这项研究引入了一种用于光动力学疗法 (PDT) 的新光敏剂,它在低氧条件下有效工作,并使用近红外光来更好地透组织,克服当前癌症治疗的关键局限性.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
摄影化学的使用.

背景情况:

光动力疗法 (PDT) 是一种有前途的癌症治疗方法,但由于缺氧瘤的氧气依赖性和光线透性差,其受限.
现有的光敏感剂 (PSs) 可能具有黑暗毒性,需要短波长的光,阻碍临床应用.
固体瘤的缺氧显著降低了传统的依赖氧气的PDT的疗效.

研究的目的:

开发一种新型的低氧活性光敏感剂 (PS) 用于近红外 (NIR) 光动力学疗法 (PDT).
在癌症治疗中,创建一个可以克服氧气依赖和组织透能力差的PS.
设计一种结合生物成像和光疗能力的治疗药物.

主要方法:

一个循环金属化 (((II) 聚烯基复合物的结合,与一个 NIR 发射 COUPY 染料.
评价水溶性,黑暗稳定性,光稳定性和Ru (II) -氨酸合物的发光特性.
在正常和缺氧条件下使用740nm光照射对癌细胞产生反应性氧物种 (ROS) (单氧氧,超氧基离子) 和光毒性的评估.

主要成果:

这种新型的Ru (II) - 氨酸合物表现出良好的水溶性,稳定性和光稳定性.
观察到单片氧和超氧基离子的有效生成.
即使在低氧条件下 (2% O2) 使用740nm光线,也可以实现对癌细胞的高光活性.
在黑暗中,PS的毒性很低,这表明它具有良好的安全性.

结论:

开发的NIR和低氧活性Ru(II) -氨酸合物有效地克服了与氧气依赖和组织透相关的PDT限制.
这种基于Ru(II) 的光敏剂显示出作为联合生物成像和光疗的治疗剂的潜力.
结合Ru(II) 复合物与可调节的COUPY光体的战略为开发先进的PDT剂提供了一个有前途的途径.

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