在肝脏捐赠者中,脂肪肝的长期风险
Ryoichi Goto1, Norio Kawamura2, Masaaki Watanabe2
1Department of Gastroenterological Surgery I Hokkaido University Graduate School of Medicine Sapporo Japan.
Annals of gastroenterological surgery
|July 7, 2023
概括
活着的肝脏捐赠者的长期安全至关重要. 脂肪肝捐赠后影响14.2%的捐赠者,男性性别和较高的BMI是危险因素,需要仔细跟踪.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植手术 移植手术
- 胃肠病学 胃肠病学
背景情况:
- 活体供体肝移植 (LDLT) 已有30年的历史,允许长期评估供体安全性.
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 评估活体捐赠者的肝切除术后肝脏健康状况至关重要.
研究的目的:
- 评估活体肝脏捐赠者的长期安全性.
- 专注于肝脏捐赠后脂肪肝疾病的发病率和危险因素.
- 为了确定捐赠后脂肪肝发育的预测因子.
主要方法:
- 评估了一组212名活着的肝脏捐赠者 (1997-2019) 的队列.
- 计算机断层扫描 (CT) 扫描被用于评估肝脏肥胖症 (>1年捐赠后).
- 脂肪肝被定义为肝脏与脏 (L/S) 的比率<1.1.1.
主要成果:
- 14.2%的捐赠者患有脂肪肝 (捐赠后平均5.3年).
- 在捐赠后15年,累计发病率达到27.7%.
- 男性性别,儿科接受者和捐赠时的BMI>25是脂肪肝的独立风险因素.
结论:
- 活着的肝脏捐赠者,特别是那些具有已确定的风险因素的肝脏捐赠者,需要保持警的监测.
- 预防和管理代谢综合征在捐赠后的护理中至关重要.
- 长期的供体安全是肝移植计划中的一个关键考虑因素.
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