印制基因:基因组保护,转录基因动力学和健康和疾病中的现象学意义
Shane A Carrion1, Jennifer J Michal1, Zhihua Jiang1
1Department of Animal Sciences and Center for Reproductive Biology, Washington State University, Pullman WA 99164-7620, USA.
International journal of biological sciences
|July 7, 2023
概括
基因组印记,一个关键的表观遗传过程,在物种中显示出不同的进化,表达和疾病模式. 印记基因,特别是父性表达的基因,表现出独特的角色和集群,影响各种生物功能和疾病.
科学领域:
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 进行比较基因组学.
背景情况:
- 1991年发现的基因组印记涉及复杂的调节机制,并与各种疾病有关.
- 以前对印记基因的研究范围,组织类型和资源有限,造成了对比分析的差距.
研究的目的:
- 在五种物种的印记基因组 (IGS) 中识别趋势和动机.
- 分析印制基因的进化保存,组织特异性表达和健康现象.
主要方法:
- 收集了五种物种当前文学中的印记基因.
- 分析了进化保护,跨组织的基因表达模式,以及相关的表型数据.
主要成果:
- 印制基因显示进化保护减少,非编码RNA的比例更高,同时保持合成.
- 母性表达基因 (MEGs) 和父性表达基因 (PEGs) 在组织表达和生物通路中表现出不同的作用.
- 与性别差异化基因相比,印制基因显示出更广泛的组织表达,对组织特定作用的偏好,以及有限的途径参与.
- 人类和小鼠印记基因具有相似的表型趋势,与性别差异化基因不同,对精神和神经系统疾病有显著影响.
- 国际基因组学表明了明确的基因组聚类,PEGs比MEGs有显著的代表性.
结论:
- 基因组印记在物种中展示了保留但独特的模式,影响了基因调节,表达和疾病表型.
- 该研究强调了印记基因,特别是PEGs的独特生物学作用和进化轨迹,以及它们与特定疾病类别的关联.
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