在通过肠道营养养的小猪中,脂肪酸因脂质乳液和组织样本而异
Mirielle L Pauline1, Caitlin Huynh1, Pamela R Wizzard1
1Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
JPEN. Journal of parenteral and enteral nutrition
|July 7, 2023
概括
混合脂类乳液 (MLE) 与以大豆为基础的脂类乳液 (SLE) 相比,与小猪的阿拉基酸 (AA) 水平较低有关. 这一发现支持当前关于MLE剂量在亲肠道营养中的做法.
科学领域:
- 生物化学 生化学
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
背景情况:
- 肠道衰竭儿童的肠道营养 (PN) 通常使用基于大豆的脂质乳液 (SLE) 或混合脂质乳液 (MLE).
- MLE含有添加的阿拉基酸 (AA) 和多可沙赫萨酸 (DHA),在必需脂肪酸含量方面与SLE不同.
- 这项研究调查了血清和组织中的脂肪酸概况,当这些乳液在不受限制的剂量中被施用时.
研究的目的:
- 为了在接受SLE和MLE的新生猪中比较血清和组织脂肪酸成分,在不受限制的剂量中.
- 评估MLE对关键组织中必需脂肪酸水平,特别是AA和DHA的影响.
主要方法:
- 新生猪被分为两组,接受SLE (n=15) 或MLE (n=15) 在10-15g/kg/day的PN 14天.
- 使用气液色谱分析了血清,大脑和肝脏的脂脂肪酸成分.
- 结果在两个乳液组之间进行了比较,并与对照猪仔 (n=8) 的参考值进行了比较.
主要成果:
- 与SLE相比,MLE的使用导致血清,肝脏和大脑脂中的林诺酸 (LA),AA和DHA水平显著降低,而DHA水平更高.
- 与对照组相比,受MLE养的小猪体现出明显降低的血清和组织AA水平.
- 相反,在接受MLE.的猪仔的血清,肝脏和大脑中,DHA水平升高.
结论:
- 与SLE和对照组相比,在小猪中不限量的MLE剂量与较低的血清和组织AA水平有关.
- 低组织AA的潜在功能后果需要进一步研究.
- 这些发现支持目前的临床实践,即避免在亲肠营养中限制MLE的剂量.
关键词:
脂肪酸 脂肪酸 脂肪酸 脂肪酸胃肠病学 胃肠病学脂质 脂质 脂质 是一种肝脏疾病是一种肝脏疾病.新生儿们的新生儿营养评估 营养评估营养支持团队 营养支持团队亲肠营养 亲肠营养儿科 儿科 儿科 儿科短肠综合征是什么意思更多相关视频
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