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用多尔佐胺充满眼科植入物治疗玻璃眼瘤的准备和表征研究
Samet Özdemir1, Egemen Çakırlı2, Bilge Sürücü2
1İstanbul Health and Technology University, Faculty of Pharmacy, Department of Pharmaceutical Technology, İstanbul, Türkiye.
Turkish journal of pharmaceutical sciences
|July 7, 2023
概括
使用碳氧甲基纤维素 (CMC) 和奇托 (CHI) 的新型眼科植入物可提供延长的多佐胺 (DRZ) 输送. CMC植入物显示出更优异的药物保留率和更慢的释放率,这表明绿眼的治疗有效.
科学领域:
- 眼科药物输送 眼科药物输送
- 生物材料科学 生物材料科学
- 制药技术 制药技术 制药技术
背景情况:
- 青光眼的治疗需要持续向眼睛表面输送药物.
- 传统的眼滴配方在药物保留和患者遵守方面存在局限性.
- 开发先进的眼科植入物可以改善治疗结果.
研究的目的:
- 使用碳氧甲基纤维素 (CMC) 和奇托 (CHI) 构建和表征多佐胺 (DRZ) 装载的眼科植入物.
- 评估植入物的物理化学性质,机械特性和生物粘合性.
- 评估体外和体外药物释放动力学和眼睛表面保留.
主要方法:
- 使用溶剂造技术制备基于CMC和CHI的眼科植入物.
- 物理化学表征包括机械测试 (拉力强度,破裂时的延长) 和生物粘合性研究.
- 进行了体外和体外药物释放研究,并与释放动力学相关联.
主要成果:
- 装有多佐胺的植入物表现出适当的机械性能,拉伸强度在10.70至11.68MPa之间.
- 在体外药物释放跟随Higuchi动力学,表明持续释放.
- 与CHI植入物相比,CMC植入物显示出明显较慢的释放率和增强的眼球表面药物保留率.
结论:
- 基于CMC和CHI的眼科植入物均可促进多佐胺的延长药物输送.
- 基于CMC的植入物在释放速度较慢和药物保留率增加方面提供了卓越的性能.
- 装有多佐胺的CMC植入物显示出有效的玻璃眼病管理的巨大潜力.
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