系统性炎症指数预测腹透析患者的全因死亡率
Yan Yang1, Yuanyuan Xu1, Shusu Liu1
1Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Renal failure
|July 7, 2023
概括
系统性炎症指数,包括系统性炎症总指数 (AISI),系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI),有效预测腹膜透析患者的死亡率. 这些标记物水平较高表明风险更高,有助于临床管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 炎症研究的研究.
- 发现生物标志物的发现.
背景情况:
- 慢性炎症是经过腹膜透析 (PD) 的患者经常出现的并发症.
- 确定PD患者死亡率的可靠预测因素对于改善患者的治疗结果至关重要.
研究的目的:
- 评估系统性炎症总指数 (AISI),系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 对PD患者全因死亡率的预测能力.
主要方法:
- 这是一项单一中心的回顾性研究,涉及369名PD患者.
- 接收器操作特征 (ROC) 曲线分析以确定最佳切断值和预测能力 (AUC).
- 卡普兰-梅尔曲线,日志级别测试和考克斯比例危险回归来评估生存率和独立的预后能力.
主要成果:
- 系统性免疫炎症指数 (SII) 显示了最高的预测值 (AUC = 0.644),其次是AISI (AUC = 0.617) 和SIRI (AUC = 0.612).
- 较高的AISI,SII和SIRI水平与较低的存活率显著相关.
- 在调整了混因素后,高AISI,SII和SIRI仍然是所有原因死亡率的独立预测因素.
结论:
- AISI,SII和SIRI是PD患者全因死亡率的有价值的独立指标.
- 这些炎症指数提供了可比的预测价值,可以帮助临床医生优化PD患者管理.
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