炎症生物标志物可以预测患有勃起功能障碍的患者对固酶5型抑制剂治疗的反应
Metin Kilic1, Anil Erkan2, Salim Zengin2
1Department of Urology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Türkiye. metinkilic1978@outlook.com.
Investigative and clinical urology
|July 7, 2023
概括
单细胞/高密度胆固醇比率 (MHR) 预测了针对勃起功能障碍 (ED) 的固酶5型抑制剂 (PDE5i) 的反应. 较高的MHR表明ED的男性对PDE5i治疗的反应更好.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 心脏病学 心脏病学
- 炎症生物标志物 炎症生物标志物
背景情况:
- 勃起功能障碍 (ED) 是一种影响生活质量的常见疾病.
- 固酶5型抑制剂 (PDE5i) 是ED的第一线治疗方法.
- 预测PDE5i的反应对于有效的ED管理至关重要.
研究的目的:
- 评估基于炎症的比率在预测ED患者PDE5i反应中的临床实用性.
- 评估中性细胞/淋巴细胞比率 (NLR),血小板/淋巴细胞比率 (PLR),淋巴细胞/单细胞比率 (LMR) 和单细胞/高密度脂蛋白胆固醇比率 (MHR).
主要方法:
- 对185名开始PDE5i治疗的ED患者进行前性研究.
- 患者被分为治疗后不响应 (IIEF-5 < 22) 和响应 (IIEF-5 ≥ 22) 的患者.
- 分析了人口统计数据和炎症标志物 (NLR,PLR,LMR,MHR).
主要成果:
- 年龄较小和MHR较高独立地与更好的PDE5i反应有关.
- 在响应组和不响应组之间观察到LMR和MHR的显著差异.
- 多变量分析证实MHR是一个重要的预测因素.
结论:
- 单细胞/高密度脂蛋白胆固醇比率 (MHR) 是ED中PDE5i治疗反应的独立预测因子.
- MHR可能有助于识别可能受益于PDE5i治疗的患者.
- 需要进一步的研究来探索其他影响治疗失败的因素.
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