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通过p110γ螺旋域的构造变化介导的PI3Kγ的Allosteric激活或抑制

Noah J Harris1, Meredith L Jenkins1, Sung-Eun Nam2

  • 1Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.

eLife
|July 7, 2023
PubMed
概括

新的研究揭示了氏酸3-激酶 (PI3Kγ) 的螺旋域在免疫信号传递中起着关键的调节作用. 这一发现为开发用于治疗干预的全抑制剂开辟了新的途径.

关键词:
在HDX-MS中使用HDX-MS.在PI3K中,PI3K是指PI3K.PI3Kγγ 的意思是这就是PIK3CGCG.这就是PIK3R5R5.生物化学 生物化学化学生物学 化学生物学人类 人类 人类 人类 人类 人类 人类分子生物物理学分子生物物理学纳米体是一个纳米体.p101 一个人的生活结构生物学结构生物学

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