在SARS-CoV-2感染者中概述了AD的病理生理特征
Elizabeth Griggs1, Kyle Trageser1, Sean Naughton1
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, United States.
eLife
|July 7, 2023
概括
COVID-19感染会影响大脑功能,导致神经炎症和血脑屏障问题,类似于阿尔茨海默病. 额叶皮和海马体的这些变化为治疗神经PASC患者的认知衰退提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2 (PASC) 后急性后果可能会影响认知.
- 怀疑大脑中的神经病理生理变化.
- 阿尔茨海默病 (AD) 也会导致认知障碍.
研究的目的:
- 为了评估SARS-CoV-2感染的神经病理生理后果.
- 在COVID-19,AD和共感染个体中比较大脑变化.
- 识别共同和独特的病理特征.
主要方法:
- 在布罗德曼区域9 (BA9) 和海马体形成 (HF) 中检查了转录和细胞特征.
- 与SARS-CoV-2,AD和SARS-CoV-2感染的AD个体与对照进行了比较.
- 评估神经炎症,血脑屏障完整性,微质变化 (Iba-1),以及HIF-1α表达.
主要成果:
- 在SARS-CoV-2,AD和共感染个体中观察到神经炎症和血脑屏障完整性的共同变化.
- SARS-CoV-2 感染导致共同感染的个体发生结节性微质形态变化.
- 在感染SARS-CoV-2的个体中,无论AD状态如何,HIF-1α在两个大脑区域都显著上调.
结论:
- 感染SARS-CoV-2会导致大脑中的神经病理生理变化.
- 这些发现表明神经PASC的潜在治疗点.
- 早期识别患有AD并发症风险的个体至关重要.
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