在加拿大治疗严重喘时,tzepelumab的成本效益
Mara Habash1, Hannah Guiang2, Irvin Mayers3
1AstraZeneca Canada, Mississauga, Canada.
Journal of medical economics
|July 7, 2023
概括
与标准护理相比,Tezepelumab为加拿大的严重喘患者提供了更好的结果,提供了更多的生命年和质量调整生命年 (QALYs). 这种新疗法也被证明比现有的生物疗法更有效,更便宜.
科学领域:
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 严重的喘会影响患者的生活质量和医疗保健资源的利用.
- 目前的治疗指南建议标准护理 (SoC),包括高剂量的吸入性皮质类固醇和长效β激动剂.
- 添加新型疗法,如tzepelumab旨在改善喘控制和减少恶化.
研究的目的:
- 评估tezepelumab作为加拿大严重喘的附加维护疗法的成本效益.
- 为了比较tzepelumab加SoC与单独的SoC和其他被补偿的生物制品.
主要方法:
- 使用五个健康状态的马尔科夫队列模型进行成本效益分析.
- 使用了NAVIGATOR和SOURCE试验中的有效性数据.
- 应用了加拿大公共付款人的50年时间视野和1.5%的折扣率.
主要成果:
- 与SoC单独相比,Tezepelumab加SoC的增量成本效益比为每获得的质量调整寿命年 (QALY) 为192,357美元.
- 德泽佩卢马布在目前偿还的生物药物上表现出主导地位,以更低的成本提供更高的QALY.
- 概率分析表明,tzepelumab在各种支付意愿门中具有最高的成本效益概率.
结论:
- 与加拿大严重喘的标准护理相比,Tezepelumab提供了显著的临床益处,包括额外的寿命年和QALY.
- 德泽佩卢马布是一种具有成本效益的选择,在有效性和成本方面主导着现有的生物疗法.
- 这些发现支持tezepelumab作为加拿大医疗保健系统中严重喘患者有价值的治疗选择的价值.
关键词:
加拿大加拿大加拿大加拿大加拿大加拿大D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D D 在线观看 在线观看 在线观看D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D6 D7 D7 D7 D8 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9 D9D61 D61 D61 D61 这是一个很好的例子.我已经开始了,我已经开始了.第111章 这是一件好事一千一百零一年 一百一十年严重的喘 严重的喘经济效益性 经济效益性成本效益分析 成本效益分析泰泽佩卢姆巴姆的情况是这样的
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