更新:母亲补充,甲状腺功能测试和儿童神经发育结果
1Departments of Clinical Medicine, Obstetrics, and Gynecology, Division of Endocrinology, Metabolism, and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
概括
在轻度至中度缺乏地区,孕妇在怀孕期间补充对甲状腺功能和儿童神经发育的影响尚不清楚. 需要更多的研究,因为目前的数据是混合的,过量摄入是有害的.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 轻度至中度的缺乏症 (MMID) 在全球范围内在孕妇群体中持续存在,尽管有盐化的努力.
- 目前在怀孕期间的摄入量不足,全球超过一半的孕妇.
- 在MMID地区关于母亲状况和妊娠结果的现有数据是相互矛盾的.
研究的目的:
- 审查目前对孕妇补充 (MIS) 在怀孕中的影响的理解.
- 在MMID中评估对母亲甲状腺功能和儿童神经发育结果的影响.
- 识别与怀孕期间摄入相关的知识差距和风险.
主要方法:
- 审查最近的元分析和随机对照试验.
- 对调查母亲状况和补充剂的队列研究的分析.
- 对母亲甲状腺功能标志物和婴儿神经认知数据的评估.
主要成果:
- 最近的研究表明,关于MIS和盐化的有效性来实现充足的混合结果.
- 一些研究表明,MIS对母亲的甲状腺激素有潜在的益处,而另一些研究则显示没有足够的改善.
- 分析没有证明MIS对MMID群体婴儿神经认知结果的明显益处.
- 怀孕期间过量摄入的患病率很大 (52%),存在风险.
结论:
- 缺乏高质量的数据支持MMID地区的常规MIS.
- 仅仅盐的化可能不足以满足怀孕期间的需求.
- 某些饮食习惯增加了充足的状态的风险;必须避免过量摄入.
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