在一般人群中,ANP遗传变异rs5068对代谢保护的性别差异
Tomoko Ichiki1,2, Valentina Cannone1,3, Christopher G Scott4
1Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, United States.
概括
心房 natriuretic (ANP) 基因变异 rs5068 与男性改善的代谢健康有关,这表明 ANP 在代谢恒温中起着保护作用. 在这项研究中,B型性尿素 (BNP) 基因变异rs198389没有显示出任何显著的关联.
科学领域:
- 心血管生理学心血管生理学
- 代谢的恒常状态 代谢的恒常状态
- 遗传学 遗传学 是一个
背景情况:
- 耳前 natriuretic (ANP) 和B型 natriuretic (BNP) 是调节血压和代谢平衡的心脏激素.
- 与女性相比,男性患心血管疾病风险因素的患病率更高.
- 与ANP和BNP基因变异相关的心脏代谢保护的性别差异仍未得到充分研究.
研究的目的:
- 研究与ANP (NPPA) 和BNP (NPPB) 基因变异相关的心脏代谢保护的性别差异.
- 检查ANP基因变异rs5068和BNP基因变异rs198389与一般人群中的心脏代谢参数的关联.
- 为了确定尿素在代谢恒常的作用,考虑到性别特异性的影响.
主要方法:
- 针对ANP变异rs5068和BNP变异rs198389.9的1,146名受试者的基因定型.
- 对心脏代谢参数的审查,包括血压,BMI,胰岛素水平和代谢综合征的患病率.
- 基因变异与临床/心声学参数之间的关联分析,按性别分层.
主要成果:
- ANP rs5068的小等位基因与较低的透析血压,肌素,BMI,腰围,胰岛素相关,男性肥胖和代谢综合征的患病率降低,HDL水平较高.
- 这些有利的代谢效应的趋势在女性中观察到,但没有统计学意义.
- 对于BNP rs198389变种,没有发现任何与任何测量的心脏代谢,脏或心声学参数的显著关联.
结论:
- ANP基因变异rs5068与男性的有利代谢表型有关,这表明ANP途径在代谢功能中起着保护作用.
- 在一般人群中,BNP基因变异rs198389似乎与心脏代谢参数无关.
- 这些发现凸显了性对自然尿素反应的重要性,并表明ANP在代谢恒常中起着更重要的作用,特别是在男性中.
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