类风湿性关节炎患者死亡率的时间趋势:丹麦基于人口的匹配队列研究
Bolette G Soussi1,2, Kirsten Duch1, René L Cordtz1
1Center of Rheumatic Research Aalborg, Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark.
Rheumatology (Oxford, England)
|July 7, 2023
概括
类风湿性关节炎 (RA) 患者的死亡风险显著下降,接近一般人口水平. 然而, RA 妇女的过度死亡率仍然存在,突出显示了持续的性别差异.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病,已知与死亡率增加有关.
- 了解RA相关死亡率的时间趋势对于公共卫生倡议和患者护理至关重要.
研究的目的:
- 为了研究与一般人群相比,类风湿性关节炎 (RA) 患者的5年全因死亡率.
- 检查RA相关死亡率的时间趋势和性别差异.
主要方法:
- 一个全国性的,基于人口的,匹配的队列研究设计.
- 从行政卫生登记册中确定了1996-2015年间诊断的RA患者,并追踪到2020年.
- 发生的RA患者与基于出生年份和性别的非RA患者相匹配1:5;进行了时间到事件分析.
主要成果:
- 与对照组相比,RA患者的风险差异从1996-2000年的3.5%下降到2011-2015年的-1.6%.
- 在1996-2000年和2011-2015年期间,60岁的RA患者的5年累计死亡率从8.1%降至2.9%.
- 在RA的女性中,死亡率仍然过高,而RA的男性在2011-2015年的死亡风险与对照组相似.
结论:
- 在RA患者中观察到5年全因死亡率的显著改善,缩小了与一般人群的差距.
- 尽管总体情况有所改善,但在RA患者中仍然存在持续的过度死亡风险,这凸显了对性别特定管理策略的需求.
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