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Updated: Jul 24, 2025

Study of Protein-protein Interactions in Autophagy Research
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Published on: September 9, 2017

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PTEN既是伴侣介导自的激活剂,也是伴侣介导自的基质

Katherine K Zhang1, Calvin M Burns2, Mary E Skinner3

  • 1College of Literature, Arts, and the Sciences, University of Michigan, Ann Arbor , Ann Arbor, MI, USA.

The Journal of cell biology
|July 7, 2023
PubMed
概括

过度表达PTEN会增强伴侣介导自 (CMA),这是调节新陈代谢和寿命的关键过程. 这项研究揭示了CMA既是PTEN的效应剂,也是调节剂,影响癌症途径.

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Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...
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Export of Misfolded Proteins out of the ER

After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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