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在垂体神经内分泌瘤 (PitNETs) 中的瘤免疫微环境:在PIT1系子集中增加M2巨细胞透和PD-L1表达

Mei Luo¹, Rui Tang², Haijun Wang³

¹Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Journal of neuro-oncology

|July 7, 2023

概括

带有PIT1血统的垂体神经内分泌瘤 (PitNETs) 显示M2巨细胞透和PD-L1表达的增加,与攻击性相关. 这表明免疫检查点抑制剂和M2向免疫疗法可能有利于这些侵略性的PitNETs.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

在垂体神经内分泌瘤 (PitNETs) 中的瘤免疫微环境 (TIME) 和免疫疗法的疗效仍然不太清楚.
下垂体转录因子可能会影响TIME,影响攻击性和转移性PitNETs的治疗策略.

研究的目的:

为了评估不同PitNET血统的免疫格局.
为了确定下垂体转录因子是否重塑了 TIME.
为了为攻击性和转移性PitNETs的免疫疗法应用提供信息.

主要方法:

在210个PitNET和8个正常垂体 (NP) 的转录组概况的in silico分析.
在77个PitNET和6个NP上进行免疫组织化学 (IHC) 验证.
在PIT1系PitNETs中,免疫成分与临床病理特征的相关性分析.

主要成果:

与TPIT系,SF1系PitNET和NP相比,PIT1系PitNET的M2巨细胞透率显著增加.
在PIT1系PitNETs中,M2巨细胞透与瘤体积正相关.
在PIT1系PitNET中,PD-L1表达高,与瘤体积和洞穴鼻腔侵袭相关.

结论:

PIT1系的PitNETs具有独特的免疫特征,其特征是M2巨丰富和PD-L1表达,有助于临床攻击性.
免疫检查点抑制剂和M2向免疫疗法可能有利于治疗侵略性和转移性PIT1系PitNETs.

关键词:

免疫治疗是一种免疫疗法.在M2巨中,巨是M2-巨.在PD-L1中.在PIT1中,PIT1是PIT1.坑洞网络 (PitNET) 是一个

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