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第三代心室辅助器件的体外流量验证:可行性和挑战

Andreas Escher¹, Bente Thamsen¹, Carsten Strauch²

¹From the Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

|July 7, 2023

概括

轮动力血 (RBPs) 的增强体内验证是可行的,但几何修改会影响局部流量和血液相容性. 全球流量量得到了可靠的验证,但地方测量需要仔细考虑,以获得准确的in-silico可转移性.

科学领域:

生物医学工程生物医学工程
流体动力学流体动力学
医疗器械医疗器械

背景情况:

计算流体动力学 (CFD) 对于评估轮动力血 (RBPs) 是至关重要的.
目前的验证通常依赖于有限的全球流量测量.
第三代RBPs如HeartMate 3 (HM3) 需要先进的验证技术.

研究的目的:

评估对HeartMate 3 (HM3) RBP进行增强体外验证的可行性和挑战.
调查几何修改对RBP性能和血红相容性预测的影响.
为了比较原始和修改几何形状的in-silico和in-vitro结果.

主要方法:

修改了HM3测试台,用于高精度的扭矩采集和光学流量测量.
在修改和原始HM3几何形状上进行了in-silico CFD模拟.
在15个操作条件中验证了全球流量计算.
在几何体之间比较全球和本地液压性能和血红相容性预测.

主要成果:

在经过修改的试验台上成功验证了全球液压性能 (压力头:r=0.999,RMSE=2.92 mmHg;扭矩:r=0.996,RMSE=0.134 mNm).
全球液压性能显示,原始和修改的几何体在中具有很好的一致性 (r > 0.999,相对误差 < 11.97%).
局部液压性能 (误差高达81.78%) 和血液相容性预测 (偏差高达21.03%) 受到几何修改的显著影响.

结论:

加强RBP的体外验证是可行的,但需要仔细考虑几何修改.
虽然全球流量特性在很大程度上仍可转移,但局部流量特征和血液相容性预测对试验台的变化很敏感.
从改造的试验台到原始设计的局部流量测量的可转移性受到重大局部影响的挑战.

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