冠状动脉慢流现象患者的同型半氨酸水平:一个元分析
Hong Yu1,2, Bei-Bei Wang3, Meng Zhao4
1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
PloS one
|July 7, 2023
概括
高水平的同类氨酸 (Hcy) 与冠状动脉慢流现象 (CSFP) 密切相关. 这种关联在CSFP患者中尤为明显,其心肌梗塞中平均血栓溶解 (TIMI) 框架数为46或以上.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 临床研究 临床研究
背景情况:
- 冠状动脉慢流现象 (CSFP) 随着冠状动脉血管学的进步越来越被认可.
- 之前关于同类氨酸 (Hcy) 水平与CSFP之间的关联的研究已经产生了相互矛盾的结果.
研究的目的:
- 进行一项元分析,以澄清同等氨酸水平与冠状动脉慢流现象之间的相关性.
- 调查观察到的关联中异质性的潜在来源.
主要方法:
- 在Embase,Web of Science和PubMed数据库中进行了全面的文献搜索,截至2022年3月.
- 包括的研究评估了Hcy水平和CSFP之间的关系.
- 采用随机或固定效应的元分析,并使用离开一个和子组分析评估异质性.
主要成果:
- 分析了13项研究,包括625名CSFP患者和550名对照.
- 与对照组相比,CSFP患者的Hcy水平显著更高 (SMD,1.45;95% CI,0.94至1.96).
- 观察到显著的异质性 (I2 = 93%),主要归因于心肌梗塞 (TIMI) 框架数 (≥46) 中的血栓溶解.
结论:
- 高水平的同类氨酸显示出与冠状动脉慢流现象的强烈关联.
- Hcy和CSFP之间的相关性在平均TIMI数为46或以上的患者中显著更强.
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