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在加拿大遵守口服抗逆转录病毒疗法,2010-2020年
Jonathan B Angel1, Jonatan Freilich2,3, Erin Arthurs4
1Division of Infectious Diseases, Ottawa Hospital-General Campus, Ottawa, Ontario, Canada.
AIDS (London, England)
|July 7, 2023
概括
在加拿大,几乎一半的艾滋病毒成年人表现出对抗逆转录病毒治疗 (ART) 的坚持不足. 在这项研究中,多片剂疗法和年轻年龄与较差的ART坚持有关.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗逆转录病毒疗法 (ART) 对于治疗艾滋病毒感染至关重要.
- 坚持ART是治疗成功和预防药物耐药性的关键.
- 了解不同人群的坚持模式对于优化艾滋病毒护理至关重要.
研究的目的:
- 评估加拿大艾滋病毒感染者 (PWH) 之间的ART坚持率.
- 为了确定与非最佳ART坚持 (<95%) 相关的基线特征.
主要方法:
- 这是一项回顾性观察性研究,利用来自加拿大七个省份 (2010-2020年) 的处方索赔数据.
- 包括18岁以上的PWH开始ART,至少12个月的随访.
- 通过覆盖日数比例 (PDC) 评估依从性;多变量回归分析了与基线特征的关联.
主要成果:
- 分析了19,322个PWH;44.7%的人表现出低于最佳的ART坚持.
- 低于最佳的坚持与多片药片ART疗法 (P<0.001) 和年轻年龄 (P<0.001) 有显著的关联.
- 没有发现性别是ART坚持的重要因素.
结论:
- 在加拿大的成年PWH中,低于最佳的ART坚持是普遍存在的,影响了近一半的研究人口.
- 诸如多片剂疗法和年轻年龄等因素需要注意,以改善坚持.
- 对坚持决定因素的进一步研究可以为提高艾滋病毒护理和结果的策略提供信息.
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