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儿科肠道和多器官移植
Mohamed Maklad1, George Mazariegos, Armando Ganoza
1Hillman Center for Pediatric Transplantation, Thomas E. Starzl Transplantation Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Current opinion in organ transplantation
|July 7, 2023
概括
肠道和多胞体移植 (ITx,MVTx) 为患有肠道衰竭 (IF) 的儿童提供拯救生命的治疗. 虽然结果有所改善,但长期的移植功能仍然是儿科患者的重大挑战.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 移植手术 移植手术
- 器官衰竭管理 器官衰竭管理
背景情况:
- 儿童的肠衰竭 (IF) 需要先进的管理,包括腹腔营养 (PN).
- 肠道移植 (ITx) 和多胞体移植 (MVTx) 是不可逆转的IF及其并发症的关键干预措施.
- 与成人相比,儿科IF具有独特的病因和管理考虑因素.
研究的目的:
- 审查儿科患者肠道和多胞体移植的独特方面.
- 讨论儿科ITx和MVTx的不断变化的指示.
- 突出儿科特定的外科手术挑战和结果.
主要方法:
- 关于儿科肠道和多胞体移植的当前文献的综述.
- 对患者和移植存活率的多中心注册表数据的分析.
- 讨论儿科特定的外科手术技术和移植后护理.
主要成果:
- 在多中心报告中,患者长期生存率为66.1%,移植后5年生存率为48.8%.
- 在FI管理和家庭PN方面的进步导致了移植指示标准的更新.
- 儿科ITx和MVTx可以挽救生命,但面临挑战,特别是在长期移植功能方面.
结论:
- ITx和MVTx是儿科IF的必要治疗方法,提供更好的生存率.
- 持续的挑战包括优化长期的移植功能和解决儿科特定的外科问题.
- 持续的研究和管理协议的更新对于改善儿科移植的结果至关重要.
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