皮炎患者的恶性瘤风险:基于人口的队列研究
Joy Wan1, Daniel B Shin2, Maha N Syed2
1Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
The British journal of dermatology
|July 7, 2023
概括
这项研究发现,在患有亚托皮性皮肤炎 (AD) 的儿童和成人中,整体癌症风险没有增加. 然而,严重的AD与淋巴瘤的更高风险有关,轻度的AD与非黑色素瘤皮肤癌有关.
科学领域:
- 皮肤病学和瘤学
- 流行病学 流行病学
- 免疫皮肤学 免疫皮肤学
背景情况:
- 亚托皮炎 (AD) 涉及免疫功能障碍,可能影响癌症的发展.
- 以前关于AD和癌症的研究结果不一致,对儿科患者群体或AD严重程度的数据有限.
- 了解AD严重程度,治疗和恶性瘤风险之间的关系至关重要.
研究的目的:
- 调查亚托邦性皮肤炎 (AD) 与儿童和成年人患各种恶性瘤的风险之间的联系.
- 分析AD严重程度,按治疗和专家转诊分类,如何影响特定的癌症风险.
- 在一个大队伍中提供有关AD和癌症风险的最新流行病学证据.
主要方法:
- 一项基于英国的队列研究利用了1994-2015年的电子健康记录.
- 患有AD的儿童和成人与没有AD的对照进行了匹配,AD的严重程度分为轻度,中度或严重.
- 主要结局是发生的恶性瘤 (所有类型),次要结局包括特定癌症,如白血病,淋巴瘤,黑色素瘤和非黑色素瘤皮肤癌 (NMSC).
主要成果:
- 在儿童中,AD和对照组的恶性瘤总体风险相似;然而,严重的AD与淋巴瘤风险增加相关,轻度的AD与NMSC风险增加相关.
- 在成年人中,总体恶性瘤风险没有显著不同,但严重的AD显示非皮肤T细胞淋巴瘤 (非CTCL) 的风险增加了两倍.
- 阿尔茨海默病与整体皮肤癌风险略有增加和固体癌症风险略有降低有关,因特定癌症类型和阿尔茨海默病的严重程度而有所不同.
结论:
- 目前的流行病学数据并不表明与亚托皮性皮肤炎 (AD) 相关的恶性瘤风险的总体大幅增加.
- 严重的AD可能与淋巴瘤的风险增加有关,特别是在成年人中非CTCL.
- 进一步的研究可能会澄清AD严重程度,特定癌症类型和免疫因素之间的微妙关系.
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