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Updated: Jul 24, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

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作为拓酶II选择性抗癌剂的二因登皮里丁:设计,合成和结构-活性关系

Aarajana Shrestha1, Soo-Yeon Hwang2, Surendra Kunwar3

  • 1College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea; Department of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, KY 40508, USA.

Bioorganic & medicinal chemistry
|July 7, 2023
PubMed
概括

研究人员开发了新的di-indenopyridine化合物,以Topoisomerase II alpha (Topo IIα) 为向,作为抗癌剂. 化合物17可选择性地催化抑制Topo IIα,在没有Topo II毒素的毒性的情况下显示出显著的抗增殖作用.

关键词:
反扩散活动的反扩散活动.- - 因多皮里迪因.结构与活动之间的关系.拓糖酶是一种多糖酶.托皮索马酶抑制可以抑制.

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Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples10:13

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