在慢性血液透析患者中,sarcopenic肥胖及其与肌肉质量和死亡率的关系
Alice Sabatino1, Carla Maria Avesani2, Giuseppe Regolisti3
1Nephrology Unit, Parma University Hospital, and Department of Medicine and Surgery, University of Parma, Parma, Italy.
Clinical nutrition (Edinburgh, Scotland)
|July 7, 2023
概括
在血液透析的末期脏病患者中,sarcopenic肥胖和肌肉脂肪透是常见的. 这两种情况都与这种脆弱人群的死亡风险显著增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 老年病的医生 老年病的医生
- 身体组成分析 身体成分分析
背景情况:
- 在接受血液透析 (HD) 的末期病 (ESKD) 患者中,肉症和肥胖是常见的,可能会影响结果.
- 肥胖症 (sarcopenic obesity) 是低肌肉质量和多余脂肪的结合,与一般人群的脆弱性和死亡率有关.
- 肌肉脂肪透 (骨髓炎) 影响肌肉强度,但在病学中没有得到充分研究.
研究的目的:
- 通过腹部CT诊断的sarcopenic肥胖症与HD患者的死亡率之间的关联.
- 在这个队列中探索骨髓炎,sarcopenic肥胖症和死亡风险之间的关系.
主要方法:
- 追溯分析212名ESKD患者的HD,使用未增强的腹部CT扫描进行评估.
- 由低骨肌面积和高总脂肪面积定义的sarcopenic肥胖症;肌肉骨病通过肌肉间和肌肉内脂肪评估.
- 考克斯回归分析用于确定与sarcopenic肥胖和骨髓硬化相关的死亡风险.
主要成果:
- 在19.8%的患者中诊断出了sarcopenic肥胖症,并且与增加的死亡率显著相关 (HR: 3.29).
- 存在的sarcopenic肥胖与肌肉骨病相关.
- 肌肉间脂肪区域和低衰减肌肉区域都独立地与调整后更高的死亡风险有关.
结论:
- 患有sarcopenic肥胖症的患者表现出肌肉脂肪透 (骨髓炎) 的增加.
- 肥胖症和骨髓炎是血液透析患者死亡率增加的重要预测因素.
- 这些发现凸显了评估HD患者的身体组成对风险分层的重要性.
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