循环马中的雌激素-铁轴:年龄的影响
Katiuska Satué1, Esterina Fazio2, Pietro Medica2
1Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, CEU-Cardenal Herrera University, Tirant lo Blanc, 7, Alfara del Patriarca, 46115, Valencia, Spain.
Theriogenology
|July 7, 2023
概括
由于雌激素水平下降,老年马的铁代谢发生变化,影响铁的调节. 这项研究揭示了马匹的"雌激素-铁轴",将雌激醇-17β与铁,费里丁和肝素水平联系起来.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 动物生理学 动物生理学
- 矿物代谢的矿物代谢.
背景情况:
- 雌激素在女性和动物模型的铁稳态中发挥作用,这表明"雌激素-铁轴".
- 衰老与雌激素水平的降低有关,可能会损害铁调节机制.
- 之前的研究表明,周期性和孕的铁状况与雌激素模式之间存在联系.
研究的目的:
- 为了研究不同年龄的循环西班牙纯种马匹中铁 (Fe),费里丁 (Ferr),肝素 (Hepc) 和雌二醇-17β (E2) 之间的关系.
- 为了阐明潜在的"雌激素-铁轴"在关于老化和生殖周期的马匹中的作用.
主要方法:
- 在四个年龄组 (4-6,7-9,10-12,>12岁) 分析了40只西班牙纯种马.
- 血液样本是在雌性周期的特定日 (-5,0,+5,+16) 收集的.
- 测量血清中的Fe,Ferr,Hepc和E2水平.
主要成果:
- 较年长的母马 (>12岁) 与较年轻的母马 (4-6岁) 相比,显示出血清酸和肝酸的显著增加,血清铁的降低.
- 雌激素-17β水平在7-9岁的母马中最高,与费里丁和肝素有显著的负相关性,与铁有积极相关性.
- 铁和费里丁与肝素呈现负相关性,这表明肝素调节铁的调节.
结论:
- 雌激醇-17β与马匹的铁代谢之间存在直接关系,主要是通过抑制Hepcidin.
- 随着年龄的增长,降低的E2水平会减少Hepcidin的抑制,导致储存铁的增加和循环自由铁的减少.
- 这些发现支持马雌激素周期中存在"雌激素-铁轴",受与年龄相关的荷尔蒙变化影响.
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