在COVID-19疫苗接种后,多发性硬化症复发和伪复发的发生率
Amir Labani1, Scott Chou1, Kasra Kaviani1
1International Neurorehabilitation Institute, Lutherville, MD, United States.
Multiple sclerosis and related disorders
|July 7, 2023
概括
对于多发性硬化症患者来说,COVID-19疫苗是安全的. 接种疫苗后MS症状的暂时恶化很少见,大多数病例在96小时内消失,支持广泛的疫苗推.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 由于COVID-19的流行,需要快速开发疫苗.
- 有关SARS-CoV-2疫苗在多发性硬化症 (MS) 患者的安全性和疗效存在担忧.
- 现有的疫苗研究没有专门包括多发性硬化患者.
研究的目的:
- 将SARS-CoV-2疫苗接种后的MS患者的副作用 (SE) 与一般人群进行比较.
- 评估COVID-19疫苗接种后MS患者复发或伪复发的风险.
主要方法:
- 一个回顾性,单站点的队列研究,涉及250名多发性硬化症患者.
- 患者接受了FDA批准的SARS-CoV-2疫苗 (BNT162b2,mRNA-1273,Ad26.COV2.S),其中一些接受了增强剂.
- 副作用是在例行临床检查期间收集的.
主要成果:
- 在MS患者群体中没有报告急性复发.
- 在所有疫苗类型和剂量中,伪复发率很低,症状在96小时内消失.
- 詹森/约翰逊和约翰逊 (Ad26.COV2.S) 疫苗没有报告MS恶化.
结论:
- 对于患有多发性硬化症的人来说,COVID-19疫苗接种是安全的.
- 接种疫苗后MS症状的暂时恶化 (伪复发) 是不常见的和短暂的.
- 研究结果支持建议MS患者接受批准的COVID-19疫苗和助推剂.
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