套套式弹性体管用于脉动流动的被动自我调节
Nathan Jen1, Jake Hadfield2, Guilherme M Bessa2
1Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada.
概括
研究人员开发了以人类大动脉为灵感的织物外套弹性体管,以调节脉动性流动. 这种生物灵感设计为微流体设备和医疗应用 (如ex-vivo心脏 perfusion) 提供了被动自我调节.
科学领域:
- 仿生学和生物启发的工程.
- 流体动力学和微流体学
- 材料科学与工程 材料科学与工程
背景情况:
- 脉冲式流量调节对于微流体设备和生物系统至关重要.
- 人类大动脉的多层结构启发了生物灵感的工程解决方案,用于流量控制.
- 现有的脉动流量调节方法可能很复杂,缺乏适应性.
研究的目的:
- 设计面料外套的弹性体管,用于脉动流动的被动自我调节.
- 为了研究这些生物灵感管的动态硬化行为.
- 为了评估管子在模拟循环循环流动中的有效性,模拟ex-vivo心脏 perfusion.
主要方法:
- 织物外套的弹性体管是使用 caoutchouc和针织织品制造的.
- 管子被整合到一个模拟循环循环中,复制出活体心脏 perfusion 条件.
- 测量了压力波形以评估流量调节,并对动态硬化进行了定量分析.
主要成果:
- 织物外套的弹性体管显示出有效的脉动流量调节,压力波形分析证明了这一点.
- 定量分析揭示了变形下的管道的"动态硬化"行为.
- 该设计增强了管道的耐用性,允许更大的压力和扩张而不会形成动脉瘤.
结论:
- 织物外套的弹性体管提供了一个可调节和有效的解决方案,用于脉动流动的被动自我调节.
- 这种以生物为灵感的方法为微流体和生物医学应用提供了一个强大的和可适应的平台.
- 该设计对需要控制脉动流动的管道系统具有前景,提高了诸如ex-vivo心脏 perfusion 系统等设备的安全性和性能.
相关概念视频
01:23Steady, Laminar Flow in Circular Tubes
260
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
260
01:17Autoregulation of Blood Flow
2.4K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.4K
01:14Free Jet
198
Free jets describe the flow of liquid exiting a reservoir through an opening into the atmosphere without resistance. The velocity (v) of the liquid jet is derived using Bernoulli's principle and expressed as:
198
01:29Gradually Varying Flow
88
Gradually varying flow (GVF) in open channels describes situations where water depth changes slowly along the channel due to factors like non-uniform bed slope, channel shape variations, or obstructions. This flow type occurs when the depth adjusts gradually to balance gravitational forces, shear forces, and energy requirements, resulting in a low rate of depth change.Characteristics of Gradually Varying FlowGVF is commonly observed in natural streams, rivers, and canals, where flow depth...
88
01:17Steady, Laminar Flow Between Parallel Plates
243
Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.
243
01:07Laminar and Turbulent Flow
8.6K
Fluid dynamics is the study of fluids in motion. Velocity vectors are often used to illustrate fluid motion in applications like meteorology. For example, wind—the fluid motion of air in the atmosphere—can be represented by vectors indicating the speed and direction of the wind at any given point on a map. Another method for representing fluid motion is a streamline. A streamline represents the path of a small volume of fluid as it flows. When the flow pattern changes with time, the...
8.6K