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Updated: Jul 24, 2025

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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综合外体测序和微阵列分析检测出遗传缺陷和肝细胞癌的潜在途径

Mei Ling Chong1, James Knight2, Gang Peng3

  • 1Department of Genetics, School of Medicine, Yale University, New Haven, CT, USA.

Cancer genetics
|July 7, 2023
PubMed
概括

整体外基因组测序确定了肝细胞癌 (HCC) 中的关键遗传变异,揭示了细胞周期和信号通路的频繁缺陷. 较高的副本数改变负担与HCC患者的预后不佳相关.

关键词:
副本编号更改负担 (CNAB)副本编号的更改 (CNAs)肝细胞癌 (HCC) 是一种肝细胞癌.身体变体的体质变体.瘤突变负担 (TMB) 是指瘤突变负担.整体外基因组测序 (WES) 测序

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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