综合外体测序和微阵列分析检测出遗传缺陷和肝细胞癌的潜在途径

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Mei Ling Chong1, James Knight2, Gang Peng3

  • 1Department of Genetics, School of Medicine, Yale University, New Haven, CT, USA.

Cancer genetics
|July 7, 2023
PubMed
概括

整体外基因组测序确定了肝细胞癌 (HCC) 中的关键遗传变异,揭示了细胞周期和信号通路的频繁缺陷. 较高的副本数改变负担与HCC患者的预后不佳相关.

关键词:
副本编号更改负担 (CNAB)副本编号的更改 (CNAs)肝细胞癌 (HCC) 是一种肝细胞癌.身体变体的体质变体.瘤突变负担 (TMB) 是指瘤突变负担.整体外基因组测序 (WES) 测序

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