评估离子对逆相,离子交换和水友相互作用液体色谱之间的正交相性,用于合成寡核酸的分离

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Updated: Jul 24, 2025

Ion Exchange Chromatography IEX Coupled to Multi-angle Light Scattering MALS for Protein Separation and Characterization
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Ion Exchange Chromatography IEX Coupled to Multi-angle Light Scattering MALS for Protein Separation and Characterization

Published on: April 5, 2019

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Matthew J Sorensen1, Mellie June Paulines1, Todd D Maloney1

  • 1Synthetic Molecule Design and Development, Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, United States.

Journal of chromatography. A
|July 7, 2023
PubMed
概括

评估了对寡核酸杂质的染色学方法的正交性. 合水友互动液态色谱 (HILIC) 与离子交换 (AEX) 或离子对逆相色谱 (IP-RP) 提供了对杂质分析的最高正交度.

关键词:
阳离子交换色谱学 阳离子交换色谱学水友互动液态色谱学 液体色谱学离子对色谱学 离子对色谱学有氧核酸类的正角性是指正角性.

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