制药行业资助和前列腺癌化疗试验:系统性审查
Amirreza Heydari1, Behnam Shakiba2, Asaad Moradi3
1School of medicine, Iran university of medical sciences, Tehran, Iran.
Cancer treatment and research communications
|July 7, 2023
概括
制药公司的资金与前列腺癌试验中更积极的化疗结果有关. 这表明,行业资金可能会影响研究结果,影响治疗决策.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 卫生经济学 卫生经济学
背景情况:
- 在临床试验中,行业资助是普遍存在的.
- 之前的研究表明,工业支持的研究往往产生更有利的结果.
- 这项研究专门研究了工业资助对前列腺癌化疗试验结果的影响.
研究的目的:
- 检查制药行业资金与前列腺癌化疗临床试验结果之间的关联.
- 将行业资助的试验结果与政府机构资助的试验结果进行比较.
主要方法:
- 对前列腺癌化疗试验的科克伦图书馆,MEDLINE和EMBASE的系统文献搜索.
- 两位独立审查员从资金来源和化疗结果中提取数据.
- 使用Cochrane批判性评估工具进行质量评估;使用odds比率分析资金来源和积极结果关联.
主要成果:
- 在91项研究中,80.2%是由行业资助的.
- 与政府资助的试验 (27.8%;P=0.010) 相比,工业资助的试验显示出明显更高的积极生存结果率 (61.6%).
- 工业融资与统计学上显著的积极生存结果的可能性更高 (OR:4.17;CI,1.34-12.99) 相关,而偏差没有显著差异.
结论:
- 尽管研究质量相似,但行业资助的试验报告了前列腺癌中更积极的化疗结果.
- 药品资助对试验结果的影响,在治疗决策中需要考虑.
- 进一步调查潜在的偏见可能是必要的,即使具有相似的质量.
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