新生儿患有先天性心脏病的血清ADAMTS-9水平
Cem Becerir1, Cüneyt Tayman1, Abdullah Kurt2
1Department of Neonatology, Ankara City Hospital, Neonatal Intensive Care Unit, University of Health Sciences, Ankara, Turkey.
American journal of perinatology
|July 7, 2023
概括
在患有先天性心脏病 (CHD) 的新生儿中,血清ADAMTS-9水平显著升高. 更高的ADAMTS-9水平可以作为诊断婴儿心脏病的预测生物标志物.
科学领域:
- 生物化学 生物化学
- 发展生物学 发展生物学
- 儿童心脏病学 儿童心脏病学
背景情况:
- 甲解体和甲蛋白酶与血栓素-9 (ADAMTS-9) 在胎儿组织中表达,并在发育中发挥作用.
- 先天性心脏病 (CHD) 是新生儿健康的一个重大问题.
研究的目的:
- 调查ADAMTS-9活动与心脏病发展之间的关联.
- 评估ADAMTS-9作为一种潜在的CHD诊断生物标志物.
主要方法:
- 对患有心脏病的新生儿和健康对照的ADAMTS-9水平的比较分析.
- 血液样本是在出生后24小时内采集的.
- 接收器运行特征 (ROC) 曲线分析以确定预测值.
主要成果:
- 与对照组 (中位数为23.36 ng/mL) 相比,心血管疾病组的ADAMTS-9水平显著更高 (中位数为46.57 ng/mL).
- >27.86 ng/mL的ADAMTS-9切断值显示了预测CHD的77.78%的灵敏度和84.78%的特异性.
- ROC分析显示,曲线下的区域为0.836,表明强大的预测能力.
结论:
- 在患有心脏病的新生儿中,血清ADAMTS-9水平显著升高.
- ADAMTS-9显示出作为一种可靠的生化标志物,用于早期诊断先天性心脏病的潜力.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
123
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
123
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
203
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
203
01:19Rh Blood Group
1.6K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.6K
01:27Development of the Heart
1.1K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
1.1K