端粒侵蚀和抑郁症状在机构护理后的整个发展过程中
Charlotte Heleniak1, Bonnie Goff2, Laurel J Gabard-Durnam3
1Columbia University, New York.
概括
早期的机构护理会扰乱发育,增加生物衰老和抑郁症状的风险. 然而,端粒长度与儿童和青少年的抑郁症没有相关性.
科学领域:
- 发展心理学 发展心理学
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
背景情况:
- 早期的护理逆境与情感精神病理学有关,特别是抑郁症,它在童年和青春期升高.
- 端粒侵蚀是生物衰老的标志物,可能会介导早期逆境和晚期抑郁行为之间的联系,但在发育过程中人们对此了解甚少.
研究的目的:
- 检查端粒长度与从学龄前到青春期的抑郁症状之间的并发关联.
- 调查早期先前的机构 (PI) 护理对端粒长度和抑郁症状随时间发展的影响.
主要方法:
- 一项加速纵向研究跟踪了暴露 (n=116) 和未暴露 (n=242) 在PI护理中的儿童的端粒长度和抑郁症状.
- 测量同时进行,并在2年和4年的随访期间进行,从学前教育到青春期.
主要成果:
- 以前的机构护理与短端粒和抑郁症状的二次年龄相关增长有关.
- 药物治疗和抑郁症状之间的关联在年幼儿童中更强,在青春期减少.
- 在这个发育样本中,端粒长度与抑郁症状并发性或预测性无关,与成人发现形成鲜明对比.
结论:
- 早期的护理中断增加了加速生物衰老和抑郁症状的风险.
- 在研究的发育期内,端粒长度和抑郁症状没有显著的相关性.
- 这些发现突出了生物衰老和早期逆境后抑郁症状的独特发育轨迹.
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