暴露于挥发性有机化合物是糖尿病的危险因素:一个横截面研究
Xueting Wang1, Weifeng He1, Xiaojuan Wu2
1Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, 100069, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
对挥发性有机化合物 (VOC) 的环境暴露与更高的糖尿病风险和胰岛素抵抗有关. 在成年人中,尿液中的特定VOC代谢物显示出与葡萄糖指标的显著积极关联.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 越来越多的证据将环境化学物质与糖尿病发展联系在一起.
- 挥发性有机化合物 (VOC) 对糖尿病的具体影响尚不清楚.
- 了解VOCs的作用对于公共卫生战略至关重要.
研究的目的:
- 调查低水平的VOC暴露与糖尿病之间的关联.
- 检查VOCs,胰岛素抵抗 (TyG指数) 和葡萄糖代谢指标 (FPG,HbA1c,胰岛素) 之间的关系.
- 分析VOC混合物对一般人群葡萄糖恒温的作用.
主要方法:
- 利用了来自NHANES数据集 (2013-2016) 的横截面数据,涉及1409名成年人.
- 使用多种线性和逻辑回归模型分析了尿液中的VOC代谢物 (mVOC) 和糖尿病指标之间的关联.
- 使用贝叶斯核机器回归 (BKMR) 进行混合物暴露分析.
主要成果:
- 多种mVOC显示与糖尿病,TyG指数,FPG,HbA1c和胰岛素有显著的积极关联.
- 尿液中的HPMMA度与糖尿病,TyG指数,FPG和HbA1c正相关.
- CEMA度与胰岛素水平有显著的相关性. 在女性和年龄在40-59岁的成年人中,相关性更强.
结论:
- 暴露于挥发性有机化合物会对胰岛素抵抗和葡萄糖平衡产生负面影响.
- 这些发现表明VOCs有助于增加糖尿病风险.
- 该研究强调了环境化学物质暴露和代谢健康的重要公共卫生影响.
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