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和多基基物质和相关的甲状腺癌风险:中国的一项病例对照研究

Haoran Li¹, Ming Yang², Jing Yang³

¹Department of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, 050017, PR China; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, PR China.

|July 7, 2023

概括

在中国的一项研究中,某些 perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 的较高水平与甲状腺癌风险降低有关. 混合物分析还表明,PFAS暴露与甲状腺癌风险之间存在逆相关性.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

perfluoroalkyl 和 polyfluoroalkyl 物质 (PFAS) 对甲状腺癌的致癌潜力仍然不确定.
了解单个PFAS原体及其对甲状腺癌风险的综合影响之间的特定关联对于公共卫生至关重要.

研究的目的:

调查十二个PFAS原体的血清度及其混合物与甲状腺癌风险之间的关系.
为了确定特定的PFAS化合物及其对甲状腺癌发病率的综合影响.

主要方法:

一项涉及中国石家庄300名参与者的病例控制研究,根据年龄和性别进行了匹配.
使用超高性能液体染色学-并联质谱学量化十二种PFAS.
统计分析包括条件后勤回归,受限立方线模型,量子g计算和贝叶斯内核机器回归来评估个体和混合效应.

主要成果:

高度的PFOA,PFNA,PFHxS,PFDA和PFUnDA与显著降低甲状腺癌的风险有关.
对于PFNA,PFDA和PFUnDA,观察到负剂量反应关系.
混合物分析显示,总体PFAS混合物与甲状腺癌风险之间存在负相关性,PFOS和PFDA是关键因素.

结论:

这项研究提供了新的证据,表明暴露于特定的PFAS原体和它们的混合物与甲状腺癌风险之间的反向关联.
这些发现凸显了PFAS在甲状腺癌发生过程中的复杂作用,需要在更大规模的前性研究中进一步调查.

关键词:

案例控制研究研究.混合物混合物混合物在PFAS中,有很多方法.和多醇基物质是多和多的.甲状腺癌是什么?甲状腺癌是什么?

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