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口水对抗COVID-19的有效性:系统审查和网络元分析

S-Y Lin¹, J-S Sun², M-C Hung³

¹Department of Dentistry, MacKay Memorial Hospital, Taipei, Taiwan.

The Journal of hospital infection

|July 7, 2023

概括

这篇评论比较了口腔冲洗来降低SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒-2) 病毒载量. 波维- (PVP-I) 显示出潜在的疗效,但由于研究的变化,结果是不确定的.

科学领域:

传染性疾病传染性疾病
病毒学病毒学
公共卫生公共卫生

背景情况:

严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 构成了全球重大健康挑战.
了解减少病毒载量和传播的干预措施对于公共卫生战略至关重要.

研究的目的:

系统地审查和比较各种口腔冲洗在减少SARS-CoV-2病毒载量的有效性.
评估口腔冲洗对临床症状和感染发生率的影响.
进行网络元分析 (NMA) 以进行定量比较.

主要方法:

随机对照试验 (RCT) 和非随机对照试验 (NRCT) 的系统搜索至2023年3月3日.
包括23项研究 (22项RCT,1项NRCT).
网络对5项涉及9项干预措施的RCT进行元分析,以减少病毒载量.

主要成果:

化 (NaCl) 最初在降低病毒载量方面排名最高,但结果在统计学上并不显著.
根据排名得分,Povidone-iodine (PVP-I) 被确定为减少SARS-CoV-2病毒载量的最可能有效的口腔冲洗.
其他测试过的冲洗包括β-环氧德 + (CDCM),过氧化 (HP),氧化 (CHX),化 (CPC) 和低酸 (HClO).

结论:

不同口腔冲洗在减少SARS-CoV-2病毒感染性,改善症状或预防感染方面的有效性仍然不确定的.
主要研究中的异质性限制了最终的结论.
需要进一步进行高质量的研究,以确定口腔冲洗对SARS-CoV-2的有效性.

关键词:

新冠病毒疾病2019年口水可以冲洗口腔.用口腔清洁剂清洗自己的嘴.波维-是一种这是唾液的唾液.严重急性呼吸系统综合征冠状病毒-2

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