曼努卡蜂蜜激活了阿里尔碳化合物受体:对皮肤炎症的影响
Abdullah A Alangari1, Matin D Ashoori2, Wisam Alwan2
1Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia; St. John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.
Pharmacological research
|July 7, 2023
概括
曼努卡蜂蜜激活阿里尔碳化合物受体 (AHR),影响皮肤平衡. 这种AHR激活解释了曼努卡蜂蜜如何减少炎症并增强皮肤屏障功能,为亚托皮疾病提供潜在的益处.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 自然产品 化学 化学
背景情况:
- 曼努卡蜂蜜 (MH) 具有已知的抗微生物,抗氧化和抗炎性质.
- 之前的研究表明,MH降低了IL-4诱导的角质细胞中的CCL26表达.
- 阿里尔碳水化合物受体 (AHR) 对于皮肤平衡至关重要,并可能调解MH效应.
研究的目的:
- 为了调查曼努卡蜂蜜的抗炎作用是否通过阿里尔碳化合物受体 (AHR) 激活来介导.
- 阐明 MH 影响皮肤平衡和炎症反应的机制.
主要方法:
- 在体外研究中使用HaCaT细胞系 (EV-HaCaT和AHR沉默HaCaT) 和初级正常人体上皮质角质细胞 (NHEK).
- 使用曼努卡蜂蜜 (MH),AHR抗体 (CH223191) 的治疗,以及对CYP1A1和CCL26表达的评估.
- 使用记者小鼠进行体内研究,以评估在MH应用后皮肤中的CYP1A1诱导.
主要成果:
- 曼努卡蜂蜜显著上调CYP1A1表达以一种依赖于AHR的方式,在体外和体内.
- MH对IL-4诱导的CCL26的降低调节在AHR沉默细胞和AHR抗剂预治疗中被废除.
- 曼努卡蜂蜜通过依赖于AHR的途径在角质细胞中调节了费拉格林 (FLG) 表达的表达.
结论:
- 曼努卡蜂蜜激活了皮肤细胞中的阿里尔碳化合物受体 (AHR).
- 由MH激活AHR为其观察到的CCL26下调和FLG上调提供了一种机制.
- 这些发现表明,曼努卡蜂蜜对亚托皮性疾病和其他皮肤疾病的潜在临床应用.
关键词:
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