与ANCA相关的血管炎患者的妊娠结果:系统性审查和元分析
Styliani Partalidou1, Apostolos Mamopoulos2, Despoina Dimopoulou1
1Fourth Department of Internal Medicine, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Joint bone spine
|July 7, 2023
概括
患有抗中性粒细胞体抗体 (ANCA) 相关血管炎 (AAV) 的女性怀孕与早产,生长限制和疾病爆发的风险增加有关. 密切监测和预孕咨询对于管理AAV怀孕至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 产科 产科 产科 产科 产科
- 系统性自身免疫性疾病
背景情况:
- 抗中性粒细胞体抗体 (ANCA) 相关血管炎 (AAV) 包括罕见的小血管系统性血管.
- 越来越多的中年女性有AAV正在考虑怀孕.
- 在AAV中妊娠并发症尚未被系统评估.
研究的目的:
- 系统地评估AAV妇女怀孕并发症的患病率.
- 评估AAV患者的不良妊娠结果.
- 为了确定AAV患者在怀孕期间疾病爆发的风险.
主要方法:
- 在PubMed,Scopus,Cochrane图书馆和Cinahl数据库中进行了全面的文献搜索,直到2022年9月.
- 数据提取和偏差风险评估由三个失明的调查人员进行.
- 一个随机效应模型分析了结果,包括早产,子宫内生长限制 (IUGR) 和疾病爆发.
主要成果:
- 包括六项涉及92例AAV患者怀孕的研究.
- 发病率为早产的18%,IUGR新生儿的20%.
- 在怀孕期间观察到28%的显著发病率 (P<0.01).
结论:
- 有AAV的孕妇面临更高的不良妊娠结果的发病率.
- 在AAV患者中,怀孕期间疾病爆发的风险增加.
- 预孕咨询和密切的母胎监测对于管理AAV怀孕至关重要.
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