在COVID-19之后的过程 心力衰竭患者的心脏衰竭患者与中度降低的左心室排泄小部分
I Rudyk1, D Babichev1, O Medentseva1
1Government Institution "L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.
Georgian medical news
|July 7, 2023
概括
COVID-19显著加剧了心力衰竭与中程射出分数 (HFmrEF) 的情况. 患有COVID-19病史的患者显示NT-proBNP,尿酸升高,生活质量降低,表明持久的心脏影响.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 中等射出率心力衰竭 (HFmrEF) 是一种重要的心血管疾病.
- COVID-19对心血管健康的长期影响,特别是在HFmrEF患者中,需要进一步调查.
研究的目的:
- 评估COVID-19对HFmrEF过程的影响.
- 确定受HFmrEF患者同时COVID-19感染影响的特定生物标志物和临床指标.
主要方法:
- 一项涉及72名HFmrEF患者和18名健康对照者的比较研究.
- 使用生物标志物分析 (素,NT-proBNP,尿酸),生活质量问卷 (EQ-5D-5L) 和心脏超声波.
- 根据COVID-19病史对HFmrEF患者进行了分组.
主要成果:
- 患有COVID-19病史的患者表现出明显更高的NT-proBNP水平 (1002.79±215.94 pg/ml与405.37±99.06 pg/ml相比) 和尿酸 (429.08±27.01 mmol/l与354.44±28.75 mmol/l相比).
- 在COVID-19阳性组中观察到较低的furin对NT-proBNP比率 (0.87±0.26对1.38±1.16) 和降低的生活质量得分 (64.21±3.04对72.81±1.82) .
- 在之前患有COVID-19的HFmrEF患者中,左心室质量指数 (LVMMi) 和心房尺寸 (LA,RA) 的增加.
结论:
- 冠状病毒感染会加剧HFmrEF,导致心内血动力学障碍和持续的负面心脏结构变化.
- 素与NT-proBNP的比率可以作为HF综合征对患者生活质量影响的预测指标.
- COVID-19对HFmrEF患者的心血管健康构成重大威胁,需要有针对性的监测和管理策略.
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